手段 means "means," "method," or "measure" and refers to the way something is accomplished, often with a nuance of strategy or instrumentality. It can be neutral or carry a negative connotation depending on context, as in 战争手段 (means of war) or 技术手段 (technical means).
我们需要用技术手段解决这个问题。
Wǒmen xūyào yòng jìshù shǒuduàn jiějué zhège wèntí.
We need to use technical means to solve this problem.
谈判是解决争端最好的手段。
Tánpàn shì jiějué zhēngduān zuì hǎo de shǒuduàn.
Negotiation is the best means of resolving disputes.
他不择手段地追求成功,让人反感。
Tā bù zé shǒuduàn de zhuīqiú chénggōng, ràng rén fǎngǎn.
He pursues success by any means necessary, which is off-putting.